- The incident comes several months after Russia's second city was rocked with a metro bombing in April which killed 16 people.
The blast was caused by a "homemade explosive device with the power equivalent to 200 grammes of TNT filled with lethal fragments," she said.
"The investigation is looking at all possible causes of what happened," she said, adding that a probe for attempted murder had been launched.
The incident comes several months after Russia's second city was rocked with a metro bombing in April which killed 16 people.
"Ten people have been hospitalised, their lives are not in danger," the head of Saint Petersburg investigative unit Alexander Klaus told Russian news agencies.
An emergencies ministry representative told AFP that one of the injured was in serious condition.
An AFP correspondent at the scene observed first responders and police as well as a car belonging to the Federal Security Service (FSB), which investigates acts of terror.
The building containing the supermarket did not appear to have sustained serious damage.
Police has cordoned off the area while the city's transportation authorities briefly rerouted public transport in the neighbourhood.
Passerby Galina Gustova, 58, observed the scene with horror.
"How terrible! And this happens as people are shopping ahead of the holidays," she said. "It's a good thing nobody died."
"I often buy groceries here, I wanted to go in but everything is blocked," said another local, 20-year-old Viktoria Smirnova.
"I'm a doctor, I heard on the news that there was an explosion. I live nearby and thought I could be useful," another bystander, 50-year-old Marina Bulanova, told AFP.
Sources told Russian agencies that the explosive device had been placed in a storage locker.
"About 6:30pm there was the sound of a blast. As a result, several people have been injured," the Saint Petersburg police said.
"There is no fire. All shoppers have been evacuated," an emergencies ministry representative told Interfax.
Witness Artur Yeritsyan told TASS news agency that he heard the blast and saw smoke in the shop, but that there were not a lot of customers at the time, with some victims being taken away by ambulances.
Saint Petersburg was the target of a metro bombing in April, which killed 16 and left dozens of people wounded.
The bombing was claimed by a group linked to Al Qaeda.
In July, the FSB said it had detained seven people who were preparing "acts of terror" in Saint Petersburg, particularly its railway system and major public gathering places.
Saint Petersburg is one of the cities to host the World Cup next summer in Russia, and security services have been stepping up security measures.
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